Helen DeWitt was interviewed by Lee Konstantinou over at the Los Angeles Review of Books. It's worth reading and then rereading. Joey Comeau, Man's Best Friend, Powerpoint, Hysterical Realism, and:
Information design might enable the reader to see the world through the eyes of persons with different kinds of expertise — which is to say, among other things, to see the possibilities for misunderstanding among persons with radically different frames of reference. The alternative, too often, is fiction which presents characters drawn to precision rather than the expression of feeling as obsessive, alienated, autistic, antisocial. It’s hard to believe this impoverished view of the world can lead to great fiction.